Acronyms used to represent chemotherapy combinations: PART 1 (A to E)

Acronyms used to represent chemotherapy combinations: PART 1 (A to E)

The introduction and success of combination chemotherapy for treating various cancers has elicited the ever-growing complexity of cancer treatment regimens. Today, multidrug combinations with complex dosing parameters and sequencing have become normal. As a result, a nonformal jargon of acronyms emerged to ease the communication amongst patients and oncologists. This jargon can be a mix of generic, chemical, and brand names of antineoplastics.

Highlights:

What is chemotherapy?

What is combination chemotherapy?

Acronyms to represent combination chemotherapy regimen

1. What is chemotherapy?

 

Chemotherapy is a treatment in which a cancer patient receives drugs to kill the cancer cells flourishing in the body.

 

2. What is combination chemotherapy?

 

Cancer medications are most efficacious when allocating in combination. The motive behind giving combination therapy is to use drugs that act by different mechanisms to reduce the probability of development of resistant cancer cells.

3. Acronyms to represent combination chemotherapy regimen

 

1) 7+3

Drugs: Anthracycline (daunorubicin/idarubicin) or anthracenedione

(mitoxantrone)/cytarabine

Targeted cancer: Acute myeloid leukaemia.

Duration of treatment:

The combination is known as 7+3 because the drug cytarabine is given continuously for 7 days along with short infusions of anthracycline on every first day.

2) ABVD

Drugs: Doxorubicin (Adriamycin)/ bleomycin/vincristine/dacarbazine

Targeted cancer: Hodgkin’s Lymphoma.

Duration of treatment:

ABVD chemotherapy is given as cycles of treatment i.e. a period of treatment succeeded by a period of rest that repeated constantly. Every cycle lasts for 4 weeks, chemotherapy gives on day 1 and 15. The cycles can be from two to eight.

3) AC

Drugs: Doxorubicin/cyclophosphamide

Targeted cancer: Breast cancer

Duration of treatment:

There are generally 4 to 6 cycles of this treatment, over 3-4 months. Both medications provided on the same day, every 3 weeks.

4) AI

Drugs: Doxorubicin/ifosfamide

Targeted cancer: soft tissue sarcoma

Duration of treatment:

There are various schedules through which this combination is given, depending upon patients’ condition.

5) BEACOPP

Drugs:Bleomycin/etoposide/doxorubicin/cyclophosphamide/vincristine (Oncovin)/procarbazine/ prednisone

Targeted cancer: Hodgkin lymphoma

Duration of treatment:

Each cycle of BEACOPP takes three (21 days) or two (14 days). You may have between 2 to 8 cycles of this treatment.

6) BEP

Drugs: Bleomycin/etoposide/cisplatin

Targeted cancer: Teratoma of the ovary (a rare type of ovarian cancer)

Duration of treatment:

The BEP chemotherapy cycles depend upon:

Whether cancer has spread and how well a patient is responding to BEP. Each treatment cycle lasts for 3 weeks. You might have between 2-4 cycles of treatment.

7) CAP

Drugs: Cyclophosphamide/doxorubicin/cisplatin

Targeted cancer: Ovarian cancer

Duration of treatment:

CAP treatment is given every three weeks as a day case or over 24 hours.

8) CAPIRI

Drugs: Capecitabine/irinotecan

Targeted cancer: Colorectal cancer

Duration of treatment:

The cycles of treatment depend upon disease condition. Each cycle lasts for 21 days.

9) CAPOX

Drugs: Capecitabine/oxaliplatin

Targeted cancer: Bowel (colorectal) cancer

Duration of treatment:

Depending upon conditions, you may have 6 to 8 cycles and each lasts for 3 weeks.

10) CAV

Drugs: Cyclophosphamide/doxorubicin/vincristine

Targeted cancer: small cell lung cancer.

Duration of treatment:

Patients may have between 6 to 8 cycles and each lasts for 3 weeks.

11) CHOP

Drugs: Cyclophosphamide/doxorubicin/vincristine (Oncovin) /prednisone

Targeted cancer: Non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukaemia (CLL)

Duration of treatment:

patients may have 6-8 cycles of treatment on whole and each cycle lasts 3 weeks (21 days).

12) ChlVPP

Drugs: Chlorambucil/vinblastine/procarbazine/prednisone

Targeted cancer: Hodgkin lymphoma

Duration of treatment:

There are 6 to 8 cycles in total and each cycle lasts for 4 weeks (28 days).

13) CMF

Drugs: Cyclophosphamide/methotrexate/5-Fluorouracil

Targeted cancer: Breast cancer

Duration of treatment:

There are 4 to 6 treatment cycles and each lasts 4 weeks.

14) CODOX-M

Drugs: Cyclophsopahmide/vincristine/doxorubicin/cyclophosphamide/methotrexate/

leucovorin/intrathecal cytarabine/intrathecal methotrexate

Targeted cancer: Burkitt lymphoma

Duration of treatment:

Repeat cycle for 21 days (3weeks) for 3 cycles.

15) CVP

Drugs: Cyclophosphamide/vincristine/prednisone

Targeted cancer: Non-Hodgkin lymphoma

Duration of treatment:

There are 6-8 treatment cycles of CVP and every cycle lasts 3 weeks.

16) DHAP

Drugs: Dexamethasone/high dose cytarabine/cisplatin

Targeted cancer: Relapse high-grade non-Hodgkin lymphoma & Hodgkin lymphoma

Duration of treatment:

There are 2 to 6 cycles, each cycle lasts 3 weeks.

17) DVd

Drugs: Doxorubicin/ Bortezomib (Velcade)/dexamethasone

Targeted cancer: Multiple Myeloma

Duration of treatment:

Treatment cycles 1 – 8 are 21-day cycles, cycle 9-onwards are repeated every 28 days until disease progression.

18) ECF

Drugs: Epirubicin/cisplatin/5-Fluorouracil

Targeted cancer: Oesophageal (food pipe) cancer

Duration of treatment:

There might be 3-8 cycles of 21 days each.

19) ECX

Drugs: Epirubicin/cisplatin/capecitabine (Xeloda)

Targeted cancer: Esophageal (food pipe) cancer

Duration of treatment:

There might be 6 cycles of 21 days each.

20) ELF

Drugs: Epirubicin/leucovorin/5-Fluorouracil

Targeted drug: Stomach and oesophagal cancer

Duration of treatment:

There are upto 6 treatment cycles of ELF and each lasts for 4 weeks.

21) EOF

Drugs: Epirubicin/oxaliplatin/5-Fluorouracil

Targeted drug: Stomach and oesophagal cancer

Duration of treatment:

There are up to 8 treatment cycles of EOF and each lasts for 3 weeks.

22) EOX

Drugs: Epirubicin/oxaliplatin/capecitabine

Targeted drug: Stomach and oesophagal cancer

Duration of treatment:

There might be 6-8 cycles of 3 weeks each.

23) EP

Drugs: Etoposide/cisplatin

Targeted drug: Small cell lung cancer, germ cell cancers, cervix cancer

Duration of treatment:

The patient may have up to 6 cycles, each lasts for 3 weeks.

24) EPOCH-R

Drugs: Etoposide/prednisone/vincristine/cyclophosphamide/doxorubicin/Rituximab

Targeted drug: B-cell and T-cell non-Hodgkin lymphomas

Duration of treatment:

The patient may have 2 to 6 cycles, each lasts for 3 weeks.

25) ESHAP

Drugs: Etoposide/methylprednisolone/cytarabine/cisplatin

Targeted drug: Hodgkin lymphoma, non-Hodgkin lymphoma (NHL) and myeloma

Duration of treatment:

The patient may have 1 to 6 cycles, each lasts for 3 weeks.

These are the acronyms from alphabet A to E. Hope you will get some ease in understanding the combinations regimen by exploring this article. For the next acronym update, keep in touch.

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