Product Description
Irobenz 40/100 (Irinotecan for injection) is a liquid injection containing active drug concentrate for intravenous infusion.
Generic Name- Irinotecan
Drug Class- Antineoplastic agent
Irinotecan is a DNA topoisomerase I inhibitor which is used as a chemotherapy agent against a variety of solid tumors, such as colorectal, pancreatic, ovarian, and lung cancers. It is also used in combination with other therapeutic agents against colorectal cancer as a first- or second-line treatment. It acts by inhibiting DNA topoisomerase I, an enzyme essential for relaxation of the DNA double helix during replication and transcription. Inhibition of topoisomerase I activity leads to disruption of DNA and RNA synthesis, which ultimately results in cell cycle arrest, apoptosis and cell death.
Irobenz 40/100 (Irinotecan for injection) is a liquid injection containing active drug concentrate for intravenous infusion.
Irinotecan is indicated for:
Irinotecan, 5-Fluorouracil and Leucovorin (IFL) Regimen2 | ||
Irinotecan | 125 mg/m2 IV over 90 minutes on days 1, 8,15, 22 | |
Leucovorin | 20 mg/m2 IV infusion on days 1, 8, 15, 22 | |
5-fluorouracil | IV infusion on days 1, 8, 15, 22 every 6 weeks | |
Irinotecan, 5-fluorouracil and Leucovorin (FOLFIRI) Regimen | ||
Irinotecan | 180 mg/m2 IV over 90 minutes on days 1, 15, 29 | |
Leucovorin | 200 mg/m2 IV over 2 hours on days 1, 2, 15, 16, 29, 30 | |
5-fluorouracil | 400 mg/m2 IV infusion on days 1, 2, 15, 16, 29, 30 and 600 mg/m2 IV infusion over 22 hours on days 1, 2, 15, 16, 29, 30 | |
Irinotecan Monotherapy2 | ||
Irinotecan | 125 mg/m2 IV over 90 minutes on days 1, 8, 15, 22 then 2-week rest
OR 350 mg/m2 IV over 90 minutes on day 1 every 3 weeks |
Dosage Form and Strengths
Adverse Reactions
Contraindications
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