Product Description
Oxabenz 50/100 (Oxaliplatin for injection) is a liquid injection, which contains preservative free and sterile active drug concentrate.
Generic Name- Oxaliplatin
Drug Class- Antineoplastic agent
Oxaliplatin is a platinum derived chemotherapeutic agent which is used for the treatment of advanced colorectal cancer. It exerts its cytotoxic effects by inhibiting DNA and RNA synthesis and formation of DNA lesions. These cytotoxic effects damages DNA, initiates apoptosis and ultimately cell death.
Oxabenz 50/100 (Oxaliplatin for injection) is a liquid injection, which contains preservative free and sterile active drug concentrate.
Oxaliplatin used in combination with infusional 5 fluorouracil/leucovorin, is indicated for:
5-fluorouracil, Leucovorin and Oxaliplatin (FOLFOX4) Regimen | |
Oxaliplatin | 85 mg/m2 IV on day 1 given as a 2-hour infusion in 250 mL of dextrose 5%, concurrent with leucovorin |
Leucovorin | 200 mg/m2/day given as a 2-hour infusion |
5-fluorouracil (5-FU) | 400 mg/m2, and a 22-hour continuous infusion of 5-FU, 600 mg/m2, repeated for 2 consecutive days |
OR | |
5-fluorouracil, Leucovorin and Oxaliplatin (modified FOLFOX6) Regimen | |
Oxaliplatin, | 85 mg/m2 IV on day 1 given as a 2-hour infusion in 250 mL of dextrose 5%, concurrent with leucovorin |
Leucovorin | 400 mg/m2, given as a 2-hour intravenous infusion on day 1 |
5-fluorouracil | 400 mg/m2, on day 1 and a continuous 5-FU, 1,200 mg/m2/day, on day 1 and 2 |
Dosage Form and Strengths
Adverse Reactions
Contraindications
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